Drug interactions
Diflunisal + Nabumetone
Severity: Major
Diflunisal and Nabumetone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of two NSAIDs increases the likelihood of gastrointestinal bleeding and ulceration, renal injury and fluid retention without improving pain relief.
What this interaction means in plain words
Diflunisal and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid using two NSAIDs together; choose a single agent at the lowest effective dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Frequently asked questions
Can I take Diflunisal with Nabumetone?
MediHelp rates the interaction as major. Diflunisal and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concurrent use of two NSAIDs increases the likelihood of gastrointestinal bleeding and ulceration, renal injury and fluid retention without improving pain relief.
How serious is the interaction between Diflunisal and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two NSAIDs together; choose a single agent at the lowest effective dose.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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