Drug interactions
Diflunisal + Pegaspargase
Severity: Moderate
Diflunisal and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can cause coagulopathy and thrombocytopenia, and diflunisal impairs platelet function and irritates the gut. Together they may increase bleeding risk.
What this interaction means in plain words
Diflunisal and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Asparaginase-related reductions in clotting factors add to NSAID antiplatelet effect.
What to do
Monitor coagulation parameters and platelet count and watch for bleeding. Avoid NSAIDs during periods of marked thrombocytopenia or coagulopathy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Diflunisal with Pegaspargase?
MediHelp rates the interaction as moderate. Diflunisal and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can cause coagulopathy and thrombocytopenia, and diflunisal impairs platelet function and irritates the gut. Together they may increase bleeding risk.
How serious is the interaction between Diflunisal and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor coagulation parameters and platelet count and watch for bleeding. Avoid NSAIDs during periods of marked thrombocytopenia or coagulopathy.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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