Drug interactions
Diflunisal + Potassium iodide
Severity: Moderate
Diflunisal and Potassium iodide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise serum potassium, NSAIDs by reducing renal potassium excretion and potassium iodide by supplying potassium. The risk is higher in renal impairment or with other hyperkalemic drugs.
What this interaction means in plain words
Diflunisal and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Potassium iodide belongs to Endocrine.
Why it happens
NSAID-induced reduction in renin and aldosterone and renal perfusion decreases potassium excretion, adding to the potassium load.
What to do
Monitor serum potassium and renal function, especially with chronic use or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Potassium iodide
- Amiloride + Potassium iodide Moderate
- Amlodipine-benazepril + Potassium iodide Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Potassium iodide Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Potassium iodide Moderate
- Amlodipine-olmesartan + Potassium iodide Moderate
- Amlodipine-perindopril + Potassium iodide Moderate
Frequently asked questions
Can I take Diflunisal with Potassium iodide?
MediHelp rates the interaction as moderate. Diflunisal and Potassium iodide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise serum potassium, NSAIDs by reducing renal potassium excretion and potassium iodide by supplying potassium. The risk is higher in renal impairment or with other hyperkalemic drugs.
How serious is the interaction between Diflunisal and Potassium iodide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, especially with chronic use or renal impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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