Drug interactions
Digoxin + Dobutamine
Severity: Moderate
Digoxin and Dobutamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dobutamine is a beta-agonist that can increase myocardial automaticity and lower serum potassium. Together with digoxin this may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Digoxin and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Dobutamine belongs to Cardiovascular.
Why it happens
Additive proarrhythmic effects from increased myocardial automaticity and beta-agonist-induced potassium shifts into cells.
What to do
Monitor ECG and serum potassium and magnesium during dobutamine infusion in digitalized patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dobutamine
Frequently asked questions
Can I take Digoxin with Dobutamine?
MediHelp rates the interaction as moderate. Digoxin and Dobutamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dobutamine is a beta-agonist that can increase myocardial automaticity and lower serum potassium. Together with digoxin this may increase the risk of ventricular arrhythmias.
How serious is the interaction between Digoxin and Dobutamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium during dobutamine infusion in digitalized patients.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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