Drug interactions
Digoxin + Empagliflozin-metformin
Severity: Moderate
Digoxin and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and digoxin share renal tubular secretion pathways, and a pharmacokinetic effect on either drug is possible. Because digoxin has a narrow therapeutic index, any rise in levels can cause toxicity, and metformin accumulation risks lactic acidosis.
What this interaction means in plain words
Digoxin and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Possible competition for renal tubular cation transport, altering clearance of both drugs.
What to do
Monitor digoxin concentrations and signs of toxicity, and monitor renal function. Adjust the digoxin or metformin dose as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Digoxin and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metformin and digoxin share renal tubular secretion pathways, and a pharmacokinetic effect on either drug is possible. Because digoxin has a narrow therapeutic index, any rise in levels can cause toxicity, and metformin accumulation risks lactic acidosis.
How serious is the interaction between Digoxin and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and signs of toxicity, and monitor renal function. Adjust the digoxin or metformin dose as indicated.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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