Drug interactions
Digoxin + Epoprostenol
Severity: Minor
Digoxin and Epoprostenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol has been reported to raise serum digoxin levels slightly, though the clinical impact appears limited. Patients should still be watched for signs of digoxin toxicity.
What this interaction means in plain words
Digoxin and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Epoprostenol belongs to Genitourinary.
Why it happens
The mechanism is not established.
What to do
Check digoxin levels when starting epoprostenol if clinically indicated. Reduce the digoxin dose if levels are elevated or toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Digoxin with Epoprostenol?
MediHelp rates the interaction as minor. Digoxin and Epoprostenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Epoprostenol has been reported to raise serum digoxin levels slightly, though the clinical impact appears limited. Patients should still be watched for signs of digoxin toxicity.
How serious is the interaction between Digoxin and Epoprostenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin levels when starting epoprostenol if clinically indicated. Reduce the digoxin dose if levels are elevated or toxicity appears.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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