Drug interactions
Digoxin + Eprosartan
Severity: Minor
Digoxin and Eprosartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eprosartan has no clinically important pharmacokinetic effect on digoxin, and digoxin does not meaningfully raise serum potassium. Digoxin toxicity is potentiated by potassium disturbances and renal impairment, which can occur with ARBs, so electrolytes and renal function matter.
What this interaction means in plain words
Digoxin and Eprosartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Eprosartan belongs to Cardiovascular.
Why it happens
No direct interaction established; ARB-related changes in potassium or renal function may indirectly alter digoxin sensitivity or clearance.
What to do
Monitor serum potassium, renal function and digoxin levels or toxicity signs when starting or changing the ARB.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eprosartan
- Aliskiren + Eprosartan Contraindicated
- Eprosartan + Sparsentan Contraindicated
- Amifostine + Eprosartan Major
- Amiloride + Eprosartan Major
- Amlodipine-benazepril + Eprosartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Eprosartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Eprosartan?
MediHelp rates the interaction as minor. Digoxin and Eprosartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eprosartan has no clinically important pharmacokinetic effect on digoxin, and digoxin does not meaningfully raise serum potassium. Digoxin toxicity is potentiated by potassium disturbances and renal impairment, which can occur with ARBs, so electrolytes and renal function matter.
How serious is the interaction between Digoxin and Eprosartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and digoxin levels or toxicity signs when starting or changing the ARB.
What other medicines interact with Eprosartan?
MediHelp also lists interactions of Eprosartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Eprosartan page.
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