Drug interactions
Digoxin + Erdafitinib
Severity: Moderate
Digoxin and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erdafitinib inhibits P-glycoprotein and can raise concentrations of digoxin. This may cause digoxin toxicity given its narrow therapeutic range.
What this interaction means in plain words
Digoxin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Erdafitinib belongs to Oncology.
Why it happens
Erdafitinib inhibits P-glycoprotein, increasing digoxin absorption and reducing renal and biliary efflux.
What to do
If the combination is needed, give digoxin at least 6 hours before or after erdafitinib. Monitor digoxin levels and signs of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Erdafitinib
Frequently asked questions
Can I take Digoxin with Erdafitinib?
MediHelp rates the interaction as moderate. Digoxin and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erdafitinib inhibits P-glycoprotein and can raise concentrations of digoxin. This may cause digoxin toxicity given its narrow therapeutic range.
How serious is the interaction between Digoxin and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If the combination is needed, give digoxin at least 6 hours before or after erdafitinib. Monitor digoxin levels and signs of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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