Drug interactions
Digoxin + Eribulin
Severity: Minor
Digoxin and Eribulin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eribulin does not have an established pharmacokinetic interaction with digoxin. Cytotoxic chemotherapy in general may reduce digoxin tablet absorption, but this has not been shown for eribulin. QT prolongation from eribulin may also be relevant in cardiac patients.
What this interaction means in plain words
Digoxin and Eribulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Eribulin belongs to Oncology.
Why it happens
No established mechanism; possible reduced absorption from chemotherapy-related gut injury.
What to do
Monitor clinical response and digoxin levels if heart rate control or heart failure symptoms change during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Eribulin
Frequently asked questions
Can I take Digoxin with Eribulin?
MediHelp rates the interaction as minor. Digoxin and Eribulin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eribulin does not have an established pharmacokinetic interaction with digoxin. Cytotoxic chemotherapy in general may reduce digoxin tablet absorption, but this has not been shown for eribulin. QT prolongation from eribulin may also be relevant in cardiac patients.
How serious is the interaction between Digoxin and Eribulin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and digoxin levels if heart rate control or heart failure symptoms change during chemotherapy.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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