Drug interactions
Digoxin + Ezogabine
Severity: Moderate
Digoxin and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine's N-acetyl metabolite may inhibit renal tubular secretion of digoxin, raising digoxin concentrations. Because digoxin has a narrow therapeutic index, this may lead to toxicity.
What this interaction means in plain words
Digoxin and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ezogabine belongs to Central Nervous System.
Why it happens
Inhibition of P-glycoprotein-mediated renal tubular secretion of digoxin by the ezogabine metabolite NAMR.
What to do
Monitor serum digoxin concentrations when starting or stopping ezogabine and adjust the digoxin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Ezogabine
Frequently asked questions
Can I take Digoxin with Ezogabine?
MediHelp rates the interaction as moderate. Digoxin and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine's N-acetyl metabolite may inhibit renal tubular secretion of digoxin, raising digoxin concentrations. Because digoxin has a narrow therapeutic index, this may lead to toxicity.
How serious is the interaction between Digoxin and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations when starting or stopping ezogabine and adjust the digoxin dose as needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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