Drug interactions
Digoxin + Flurbiprofen
Severity: Moderate
Digoxin and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and renal digoxin clearance, which may raise digoxin concentrations and the risk of toxicity. The effect varies between individuals and is most relevant in older patients and those with renal impairment or heart failure.
What this interaction means in plain words
Digoxin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and glomerular filtration, decreasing digoxin elimination.
What to do
Monitor serum digoxin, potassium and creatinine when starting or stopping flurbiprofen and reduce the digoxin dose if concentrations rise. Watch for signs of toxicity such as nausea, visual disturbance and arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Flurbiprofen?
MediHelp rates the interaction as moderate. Digoxin and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and renal digoxin clearance, which may raise digoxin concentrations and the risk of toxicity. The effect varies between individuals and is most relevant in older patients and those with renal impairment or heart failure.
How serious is the interaction between Digoxin and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin, potassium and creatinine when starting or stopping flurbiprofen and reduce the digoxin dose if concentrations rise. Watch for signs of toxicity such as nausea, visual disturbance and arrhythmias.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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