Drug interactions
Digoxin + Fosinopril
Severity: Minor
Digoxin and Fosinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosinopril has little consistent effect on digoxin levels, though ACE inhibitors may alter renal function and potassium, which affect digoxin toxicity risk. Clinically significant changes in digoxin concentration are not well documented.
What this interaction means in plain words
Digoxin and Fosinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Fosinopril belongs to Cardiovascular.
Why it happens
No established mechanism; changes in renal function or potassium with ACE inhibitors may indirectly affect digoxin handling.
What to do
Monitor digoxin concentration and renal function and potassium after starting fosinopril, especially in heart failure patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Fosinopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fosinopril
- Aliskiren + Fosinopril Contraindicated
- Fosinopril + Protein a column Contraindicated
- Fosinopril + Sacubitril / valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Fosinopril Major
- Amiloride + Fosinopril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Fosinopril?
MediHelp rates the interaction as minor. Digoxin and Fosinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosinopril has little consistent effect on digoxin levels, though ACE inhibitors may alter renal function and potassium, which affect digoxin toxicity risk. Clinically significant changes in digoxin concentration are not well documented.
How serious is the interaction between Digoxin and Fosinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and renal function and potassium after starting fosinopril, especially in heart failure patients.
What other medicines interact with Fosinopril?
MediHelp also lists interactions of Fosinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Fosinopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
