Drug interactions
Digoxin + Ibuprofen
Severity: Moderate
Digoxin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen can raise serum digoxin concentrations, particularly in patients with reduced renal function, and may worsen renal function and heart failure. This can lead to digoxin toxicity in vulnerable patients.
What this interaction means in plain words
Digoxin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ibuprofen belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins lowers glomerular filtration and digoxin renal clearance.
What to do
Monitor serum digoxin level, renal function and potassium when ibuprofen is started or used regularly. Reduce the digoxin dose if levels rise or toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ibuprofen?
MediHelp rates the interaction as moderate. Digoxin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen can raise serum digoxin concentrations, particularly in patients with reduced renal function, and may worsen renal function and heart failure. This can lead to digoxin toxicity in vulnerable patients.
How serious is the interaction between Digoxin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin level, renal function and potassium when ibuprofen is started or used regularly. Reduce the digoxin dose if levels rise or toxicity appears.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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