Drug interactions
Digoxin + Ifosfamide
Severity: Minor
Digoxin and Ifosfamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy causing mucositis or gastrointestinal injury may reduce absorption of digoxin tablets, lowering its effect. Ifosfamide is not a well established example of this effect.
What this interaction means in plain words
Digoxin and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Ifosfamide belongs to Oncology.
Why it happens
Possible reduced gastrointestinal absorption of digoxin with mucosal damage from chemotherapy.
What to do
Monitor digoxin levels and heart rate or rhythm control during chemotherapy. Consider using liquid or capsule digoxin formulations if absorption is a concern.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Digoxin with Ifosfamide?
MediHelp rates the interaction as minor. Digoxin and Ifosfamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chemotherapy causing mucositis or gastrointestinal injury may reduce absorption of digoxin tablets, lowering its effect. Ifosfamide is not a well established example of this effect.
How serious is the interaction between Digoxin and Ifosfamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and heart rate or rhythm control during chemotherapy. Consider using liquid or capsule digoxin formulations if absorption is a concern.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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