Drug interactions
Digoxin + Istradefylline
Severity: Moderate
Digoxin and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses, istradefylline increases exposure to P-glycoprotein substrates such as digoxin. This may cause digoxin toxicity.
What this interaction means in plain words
Digoxin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Istradefylline belongs to Central Nervous System.
Why it happens
Istradefylline inhibits P-glycoprotein, increasing digoxin absorption and reducing clearance.
What to do
Monitor serum digoxin levels and consider reducing the digoxin dose when istradefylline is started. Watch for toxicity symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Istradefylline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Istradefylline
Frequently asked questions
Can I take Digoxin with Istradefylline?
MediHelp rates the interaction as moderate. Digoxin and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses, istradefylline increases exposure to P-glycoprotein substrates such as digoxin. This may cause digoxin toxicity.
How serious is the interaction between Digoxin and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and consider reducing the digoxin dose when istradefylline is started. Watch for toxicity symptoms.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
