Drug interactions
Digoxin + Ledipasvir-sofosbuvir
Severity: Moderate
Digoxin and Ledipasvir-sofosbuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ledipasvir inhibits intestinal P-glycoprotein and can raise digoxin concentrations. Digoxin toxicity may follow in patients with a narrow margin.
What this interaction means in plain words
Digoxin and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ledipasvir-sofosbuvir belongs to Anti Virals.
Why it happens
P-glycoprotein inhibition by ledipasvir reduces digoxin efflux and clearance.
What to do
Monitor serum digoxin concentrations and signs of toxicity, and reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ledipasvir-sofosbuvir
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Ledipasvir-sofosbuvir + Phenobarbital Contraindicated
- Ledipasvir-sofosbuvir + Phenytoin Contraindicated
- Ledipasvir-sofosbuvir + Rifampin Contraindicated
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Ledipasvir-sofosbuvir + St john's wort Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ledipasvir-sofosbuvir?
MediHelp rates the interaction as moderate. Digoxin and Ledipasvir-sofosbuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ledipasvir inhibits intestinal P-glycoprotein and can raise digoxin concentrations. Digoxin toxicity may follow in patients with a narrow margin.
How serious is the interaction between Digoxin and Ledipasvir-sofosbuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and signs of toxicity, and reduce the digoxin dose if levels rise.
What other medicines interact with Ledipasvir-sofosbuvir?
MediHelp also lists interactions of Ledipasvir-sofosbuvir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Ledipasvir-sofosbuvir page.
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