Drug interactions
Digoxin + Lisinopril
Severity: Minor
Digoxin and Lisinopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lisinopril has little consistent effect on digoxin concentrations, though small changes have been reported. The more relevant concern is that renal function changes or electrolyte shifts with ACE inhibitors may alter digoxin toxicity risk.
What this interaction means in plain words
Digoxin and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Lisinopril belongs to Cardiovascular.
Why it happens
No well-established mechanism; possible minor changes in renal digoxin clearance or potassium shifts.
What to do
Monitor digoxin level, renal function and potassium when starting or changing lisinopril in patients on digoxin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lisinopril
- Aliskiren + Lisinopril Contraindicated
- Lisinopril + Protein a column Contraindicated
- Lisinopril + Sacubitril / valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
- Amifostine + Lisinopril Major
- Amiloride + Lisinopril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Lisinopril?
MediHelp rates the interaction as minor. Digoxin and Lisinopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lisinopril has little consistent effect on digoxin concentrations, though small changes have been reported. The more relevant concern is that renal function changes or electrolyte shifts with ACE inhibitors may alter digoxin toxicity risk.
How serious is the interaction between Digoxin and Lisinopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin level, renal function and potassium when starting or changing lisinopril in patients on digoxin.
What other medicines interact with Lisinopril?
MediHelp also lists interactions of Lisinopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Lisinopril page.
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