Drug interactions
Digoxin + Mechlorethamine
Severity: Minor
Digoxin and Mechlorethamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy that damages the gut mucosa can impair absorption of digoxin tablets and lower serum levels. This may reduce heart rate control or inotropic effect.
What this interaction means in plain words
Digoxin and Mechlorethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Mechlorethamine belongs to Oncology.
Why it happens
Chemotherapy-induced mucosal injury reduces intestinal absorption of digoxin.
What to do
Monitor digoxin levels and clinical response during chemotherapy. Consider liquid or capsule digoxin formulations if absorption is impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Digoxin with Mechlorethamine?
MediHelp rates the interaction as minor. Digoxin and Mechlorethamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cytotoxic chemotherapy that damages the gut mucosa can impair absorption of digoxin tablets and lower serum levels. This may reduce heart rate control or inotropic effect.
How serious is the interaction between Digoxin and Mechlorethamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and clinical response during chemotherapy. Consider liquid or capsule digoxin formulations if absorption is impaired.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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