Drug interactions
Digoxin + Meclofenamic acid
Severity: Moderate
Digoxin and Meclofenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise serum digoxin concentrations, particularly in older patients or those with heart failure or renal impairment. This can lead to digoxin toxicity, and NSAIDs can also worsen heart failure.
What this interaction means in plain words
Digoxin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Meclofenamic acid belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration decreases renal clearance of digoxin.
What to do
Monitor serum digoxin levels and renal function when starting or stopping the NSAID, and adjust the digoxin dose as needed. Watch for signs of toxicity such as nausea, arrhythmia or visual disturbance.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclofenamic acid
- Ketorolac intranasal + Meclofenamic acid Contraindicated
- Ketorolac + Meclofenamic acid Contraindicated
- Aceclofenac + Meclofenamic acid Major
- Acemetacin + Meclofenamic acid Major
- Alteplase + Meclofenamic acid Major
- Amiloride + Meclofenamic acid Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Meclofenamic acid?
MediHelp rates the interaction as moderate. Digoxin and Meclofenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise serum digoxin concentrations, particularly in older patients or those with heart failure or renal impairment. This can lead to digoxin toxicity, and NSAIDs can also worsen heart failure.
How serious is the interaction between Digoxin and Meclofenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and renal function when starting or stopping the NSAID, and adjust the digoxin dose as needed. Watch for signs of toxicity such as nausea, arrhythmia or visual disturbance.
What other medicines interact with Meclofenamic acid?
MediHelp also lists interactions of Meclofenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meclofenamic acid page.
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