Drug interactions
Digoxin + Meloxicam
Severity: Moderate
Digoxin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and raise serum digoxin concentrations, particularly in patients with heart failure or renal impairment. This may lead to digoxin toxicity.
What this interaction means in plain words
Digoxin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Meloxicam belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandins and glomerular filtration lowers digoxin renal clearance.
What to do
Monitor serum digoxin levels, renal function and potassium when meloxicam is started or stopped. Adjust the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Meloxicam?
MediHelp rates the interaction as moderate. Digoxin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and raise serum digoxin concentrations, particularly in patients with heart failure or renal impairment. This may lead to digoxin toxicity.
How serious is the interaction between Digoxin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels, renal function and potassium when meloxicam is started or stopped. Adjust the digoxin dose if concentrations rise.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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