Drug interactions
Digoxin + Metformin-pioglitazone
Severity: Minor
Digoxin and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both metformin and digoxin are cationic drugs partly cleared by renal tubular secretion, so competition could in theory raise levels of either. Clinically significant changes in digoxin concentrations with metformin appear uncommon. Digoxin toxicity in a patient with reduced renal function would be important.
What this interaction means in plain words
Digoxin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Possible competition for renal tubular secretion of cationic drugs.
What to do
Monitor digoxin concentration and renal function when starting or changing metformin, especially in older patients or those with renal impairment. Adjust digoxin dose if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Digoxin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both metformin and digoxin are cationic drugs partly cleared by renal tubular secretion, so competition could in theory raise levels of either. Clinically significant changes in digoxin concentrations with metformin appear uncommon. Digoxin toxicity in a patient with reduced renal function would be important.
How serious is the interaction between Digoxin and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration and renal function when starting or changing metformin, especially in older patients or those with renal impairment. Adjust digoxin dose if levels rise.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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