Drug interactions
Digoxin + Minocycline
Severity: Moderate
Digoxin and Minocycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics can raise digoxin levels in the small subset of patients whose gut bacteria (Eggerthella lenta) inactivate it. This is described mainly with tetracyclines and macrolides and may cause digoxin toxicity.
What this interaction means in plain words
Digoxin and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Minocycline belongs to Anti Bacterial.
Why it happens
Suppression of intestinal flora that metabolize digoxin increases its absorbed fraction.
What to do
Monitor digoxin concentrations and watch for nausea, arrhythmias or visual changes when starting minocycline. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Minocycline?
MediHelp rates the interaction as moderate. Digoxin and Minocycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics can raise digoxin levels in the small subset of patients whose gut bacteria (Eggerthella lenta) inactivate it. This is described mainly with tetracyclines and macrolides and may cause digoxin toxicity.
How serious is the interaction between Digoxin and Minocycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and watch for nausea, arrhythmias or visual changes when starting minocycline. Reduce the digoxin dose if levels rise.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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