Drug interactions
Digoxin + Moexipril
Severity: Moderate
Digoxin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors have been reported to modestly raise digoxin concentrations in some patients, and ACE inhibitor-related renal function changes or electrolyte shifts may increase digoxin toxicity. The effect is variable and usually small.
What this interaction means in plain words
Digoxin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Moexipril belongs to Cardiovascular.
Why it happens
Not firmly established; possibly reduced renal digoxin clearance due to altered renal hemodynamics.
What to do
Monitor digoxin concentration, renal function and potassium when starting or changing moexipril. Adjust the digoxin dose if toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Moexipril?
MediHelp rates the interaction as moderate. Digoxin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors have been reported to modestly raise digoxin concentrations in some patients, and ACE inhibitor-related renal function changes or electrolyte shifts may increase digoxin toxicity. The effect is variable and usually small.
How serious is the interaction between Digoxin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration, renal function and potassium when starting or changing moexipril. Adjust the digoxin dose if toxicity signs appear.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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