Drug interactions
Digoxin + Naproxen
Severity: Moderate
Digoxin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of digoxin toxicity. The effect is variable but more relevant in elderly patients and those with kidney disease.
What this interaction means in plain words
Digoxin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion lowers digoxin renal clearance.
What to do
Monitor serum digoxin level, renal function and potassium when starting or stopping naproxen. Reduce the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Naproxen?
MediHelp rates the interaction as moderate. Digoxin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of digoxin toxicity. The effect is variable but more relevant in elderly patients and those with kidney disease.
How serious is the interaction between Digoxin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin level, renal function and potassium when starting or stopping naproxen. Reduce the digoxin dose if concentrations rise.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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