Drug interactions
Digoxin + Nifedipine
Severity: Moderate
Digoxin and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may modestly raise serum digoxin concentrations, and the effect is variable between patients. In patients with a narrow margin of safety, this can contribute to digoxin toxicity such as nausea, arrhythmias and visual disturbance.
What this interaction means in plain words
Digoxin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Nifedipine belongs to Cardiovascular.
Why it happens
Nifedipine may inhibit P-glycoprotein-mediated renal and intestinal efflux of digoxin, reducing its clearance.
What to do
Check serum digoxin concentration and renal function when nifedipine is started or stopped, and adjust the digoxin dose if levels rise. Watch for signs of digoxin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nifedipine
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Nifedipine?
MediHelp rates the interaction as moderate. Digoxin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine may modestly raise serum digoxin concentrations, and the effect is variable between patients. In patients with a narrow margin of safety, this can contribute to digoxin toxicity such as nausea, arrhythmias and visual disturbance.
How serious is the interaction between Digoxin and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum digoxin concentration and renal function when nifedipine is started or stopped, and adjust the digoxin dose if levels rise. Watch for signs of digoxin toxicity.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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