Drug interactions
Digoxin + Nilotinib
Severity: Moderate
Digoxin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and may increase digoxin levels. Nilotinib also prolongs the QT interval, and digoxin toxicity may add to arrhythmic risk.
What this interaction means in plain words
Digoxin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Nilotinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of digoxin, with additive effects on cardiac conduction and repolarization.
What to do
Monitor digoxin levels, ECG (QT interval) and electrolytes, and reduce the digoxin dose if concentrations rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Digoxin with Nilotinib?
MediHelp rates the interaction as moderate. Digoxin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits P-glycoprotein and may increase digoxin levels. Nilotinib also prolongs the QT interval, and digoxin toxicity may add to arrhythmic risk.
How serious is the interaction between Digoxin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels, ECG (QT interval) and electrolytes, and reduce the digoxin dose if concentrations rise.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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