Drug interactions
Digoxin + Ofloxacin
Severity: Moderate
Digoxin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin has been reported to raise digoxin levels slightly, possibly by reducing gut bacterial inactivation or affecting P-glycoprotein transport. Elevated digoxin may cause nausea, visual changes, or arrhythmias, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Digoxin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ofloxacin belongs to Anti Bacterial.
Why it happens
Possible reduction of intestinal bacterial digoxin metabolism and altered P-glycoprotein-mediated elimination, increasing digoxin exposure.
What to do
Monitor for digoxin toxicity and check serum digoxin concentrations if symptoms occur or renal function is poor. Reduce the digoxin dose if levels are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ofloxacin?
MediHelp rates the interaction as moderate. Digoxin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin has been reported to raise digoxin levels slightly, possibly by reducing gut bacterial inactivation or affecting P-glycoprotein transport. Elevated digoxin may cause nausea, visual changes, or arrhythmias, particularly in older patients or those with renal impairment.
How serious is the interaction between Digoxin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for digoxin toxicity and check serum digoxin concentrations if symptoms occur or renal function is poor. Reduce the digoxin dose if levels are elevated.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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