Drug interactions
Digoxin + Oxybutynin
Severity: Minor
Digoxin and Oxybutynin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anticholinergics such as oxybutynin slow gastrointestinal motility, which can increase digoxin absorption, particularly with slowly dissolving tablets. Digoxin levels may rise modestly, with a risk of toxicity in susceptible patients.
What this interaction means in plain words
Digoxin and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Oxybutynin belongs to Genitourinary.
Why it happens
Reduced gastrointestinal motility prolongs digoxin dissolution and absorption time.
What to do
Monitor serum digoxin concentration and signs of toxicity when starting or stopping oxybutynin, especially in elderly or renally impaired patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxybutynin
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Oxybutynin?
MediHelp rates the interaction as minor. Digoxin and Oxybutynin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Anticholinergics such as oxybutynin slow gastrointestinal motility, which can increase digoxin absorption, particularly with slowly dissolving tablets. Digoxin levels may rise modestly, with a risk of toxicity in susceptible patients.
How serious is the interaction between Digoxin and Oxybutynin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration and signs of toxicity when starting or stopping oxybutynin, especially in elderly or renally impaired patients.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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