Drug interactions
Digoxin + Propranolol
Severity: Moderate
Digoxin and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV nodal conduction, so together they can cause bradycardia and heart block. Propranolol may also modestly raise digoxin levels in some patients.
What this interaction means in plain words
Digoxin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Propranolol belongs to Cardiovascular.
Why it happens
Additive slowing of sinoatrial and AV nodal conduction, with a possible minor pharmacokinetic effect on digoxin.
What to do
Monitor heart rate, ECG and symptoms of digoxin toxicity, and check digoxin concentrations when indicated. Reduce doses if significant bradycardia or conduction block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Propranolol?
MediHelp rates the interaction as moderate. Digoxin and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow AV nodal conduction, so together they can cause bradycardia and heart block. Propranolol may also modestly raise digoxin levels in some patients.
How serious is the interaction between Digoxin and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and symptoms of digoxin toxicity, and check digoxin concentrations when indicated. Reduce doses if significant bradycardia or conduction block occurs.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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