Drug interactions
Digoxin + Ramipril
Severity: Minor
Digoxin and Ramipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramipril has been associated with small changes in digoxin concentrations, but the effect is inconsistent and generally not clinically significant. Renal function changes or electrolyte shifts from the ACE inhibitor may indirectly affect digoxin toxicity risk.
What this interaction means in plain words
Digoxin and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Ramipril belongs to Cardiovascular.
Why it happens
No firmly established mechanism; possible minor changes in renal clearance of digoxin or electrolyte effects.
What to do
Monitor digoxin concentration, renal function and potassium when ramipril is started or the dose changed, and adjust digoxin if levels rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ramipril?
MediHelp rates the interaction as minor. Digoxin and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramipril has been associated with small changes in digoxin concentrations, but the effect is inconsistent and generally not clinically significant. Renal function changes or electrolyte shifts from the ACE inhibitor may indirectly affect digoxin toxicity risk.
How serious is the interaction between Digoxin and Ramipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentration, renal function and potassium when ramipril is started or the dose changed, and adjust digoxin if levels rise.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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