Drug interactions
Digoxin + Sacubitril-valsartan
Severity: Minor
Digoxin and Sacubitril-valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin is often used with sacubitril-valsartan in heart failure. Digoxin toxicity is potentiated by hypokalemia, while hyperkalemia from the angiotensin receptor blocker can alter conduction, so potassium shifts matter. Sacubitril-valsartan has not been shown to significantly change digoxin levels.
What this interaction means in plain words
Digoxin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Indirect pharmacodynamic effect through changes in serum potassium and renal function that influence digoxin sensitivity and clearance.
What to do
Monitor serum potassium and renal function. Check digoxin levels if renal function changes or toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Digoxin and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Sacubitril-valsartan?
MediHelp rates the interaction as minor. Digoxin and Sacubitril-valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Digoxin is often used with sacubitril-valsartan in heart failure. Digoxin toxicity is potentiated by hypokalemia, while hyperkalemia from the angiotensin receptor blocker can alter conduction, so potassium shifts matter. Sacubitril-valsartan has not been shown to significantly change digoxin levels.
How serious is the interaction between Digoxin and Sacubitril-valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function. Check digoxin levels if renal function changes or toxicity is suspected.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
