Drug interactions
Digoxin + Selpercatinib
Severity: Moderate
Digoxin and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib may increase digoxin exposure, raising the risk of digoxin toxicity such as arrhythmia and GI symptoms.
What this interaction means in plain words
Digoxin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Selpercatinib belongs to Oncology.
Why it happens
Selpercatinib inhibits P-glycoprotein, reducing digoxin efflux and clearance.
What to do
Monitor serum digoxin levels and ECG, and reduce digoxin dose if toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selpercatinib
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Selpercatinib?
MediHelp rates the interaction as moderate. Digoxin and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib may increase digoxin exposure, raising the risk of digoxin toxicity such as arrhythmia and GI symptoms.
How serious is the interaction between Digoxin and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and ECG, and reduce digoxin dose if toxicity signs appear.
What other medicines interact with Selpercatinib?
MediHelp also lists interactions of Selpercatinib with, for example, Amiodarone, Amisulpride, Amitriptyline. The full list is on the Selpercatinib page.
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