Drug interactions
Digoxin + Triamterene
Severity: Moderate
Digoxin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene may alter digoxin handling and potassium changes can modify digoxin sensitivity. Hyperkalemia from triamterene can reduce digoxin effect, while diuretic-induced electrolyte shifts can precipitate arrhythmias. Digoxin concentrations may rise through competition for renal tubular secretion.
What this interaction means in plain words
Digoxin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion of cationic drugs plus triamterene-induced potassium and electrolyte changes that alter digoxin myocardial sensitivity.
What to do
Monitor serum digoxin concentration, potassium, magnesium and renal function, and watch the ECG. Adjust digoxin dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Triamterene?
MediHelp rates the interaction as moderate. Digoxin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene may alter digoxin handling and potassium changes can modify digoxin sensitivity. Hyperkalemia from triamterene can reduce digoxin effect, while diuretic-induced electrolyte shifts can precipitate arrhythmias. Digoxin concentrations may rise through competition for renal tubular secretion.
How serious is the interaction between Digoxin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, potassium, magnesium and renal function, and watch the ECG. Adjust digoxin dose according to levels and clinical response.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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