Drug interactions
Digoxin + Trospium
Severity: Minor
Digoxin and Trospium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trospium is eliminated partly by active renal tubular secretion, and digoxin also uses renal tubular transport. Interaction studies have not shown a clinically important change in digoxin exposure, so any effect is likely small.
What this interaction means in plain words
Digoxin and Trospium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Trospium belongs to Genitourinary.
Why it happens
Possible competition for renal tubular secretion, with limited demonstrated clinical effect.
What to do
No routine adjustment is needed; check digoxin levels and renal function if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Trospium?
MediHelp rates the interaction as minor. Digoxin and Trospium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trospium is eliminated partly by active renal tubular secretion, and digoxin also uses renal tubular transport. Interaction studies have not shown a clinically important change in digoxin exposure, so any effect is likely small.
How serious is the interaction between Digoxin and Trospium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check digoxin levels and renal function if toxicity is suspected.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
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