Drug interactions
Digoxin + Valsartan
Severity: Minor
Digoxin and Valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan has no consistent pharmacokinetic effect on digoxin in studies. However, changes in renal function or potassium with an angiotensin receptor blocker can alter digoxin exposure and toxicity risk.
What this interaction means in plain words
Digoxin and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
No direct pharmacokinetic interaction established; indirect effects through changes in renal function and potassium.
What to do
Monitor digoxin levels, renal function and potassium when starting valsartan or if renal function changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Valsartan?
MediHelp rates the interaction as minor. Digoxin and Valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Valsartan has no consistent pharmacokinetic effect on digoxin in studies. However, changes in renal function or potassium with an angiotensin receptor blocker can alter digoxin exposure and toxicity risk.
How serious is the interaction between Digoxin and Valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels, renal function and potassium when starting valsartan or if renal function changes.
What other medicines interact with Valsartan?
MediHelp also lists interactions of Valsartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Valsartan page.
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