Drug interactions
Digoxin + Vandetanib
Severity: Major
Digoxin and Vandetanib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib raises digoxin exposure through P-glycoprotein inhibition. Both drugs can affect cardiac rhythm, as vandetanib prolongs QT and digoxin toxicity can cause bradycardia and arrhythmias, so the combined risk is significant.
What this interaction means in plain words
Digoxin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Digoxin belongs to Cardiovascular; Vandetanib belongs to Oncology.
Why it happens
P-glycoprotein inhibition by vandetanib increases digoxin levels, with additive pharmacodynamic cardiac effects.
What to do
Avoid if possible; if used together, monitor ECG, electrolytes and serum digoxin levels and lower the digoxin dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Digoxin with Vandetanib?
MediHelp rates the interaction as major. Digoxin and Vandetanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vandetanib raises digoxin exposure through P-glycoprotein inhibition. Both drugs can affect cardiac rhythm, as vandetanib prolongs QT and digoxin toxicity can cause bradycardia and arrhythmias, so the combined risk is significant.
How serious is the interaction between Digoxin and Vandetanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor ECG, electrolytes and serum digoxin levels and lower the digoxin dose as needed.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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