Drug interactions
Digoxin + Vincristine
Severity: Minor
Digoxin and Vincristine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy that damages the intestinal mucosa can reduce absorption of oral digoxin tablets. This is better described with other regimens, and vincristine alone has weak evidence.
What this interaction means in plain words
Digoxin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Vincristine belongs to Oncology.
Why it happens
Chemotherapy-related mucosal injury may reduce digoxin absorption.
What to do
Monitor digoxin levels and heart rate during chemotherapy. Consider IV digoxin or liquid or capsule forms if levels are low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Digoxin with Vincristine?
MediHelp rates the interaction as minor. Digoxin and Vincristine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cytotoxic chemotherapy that damages the intestinal mucosa can reduce absorption of oral digoxin tablets. This is better described with other regimens, and vincristine alone has weak evidence.
How serious is the interaction between Digoxin and Vincristine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin levels and heart rate during chemotherapy. Consider IV digoxin or liquid or capsule forms if levels are low.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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