Drug interactions
Dihydroergotamine + Minocycline
Severity: Minor
Dihydroergotamine and Minocycline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ergotism has been reported with ergot alkaloids and macrolides, which inhibit CYP3A4, but tetracyclines are not CYP3A4 inhibitors. Any interaction with minocycline is poorly supported and most likely theoretical.
What this interaction means in plain words
Dihydroergotamine and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dihydroergotamine belongs to Central Nervous System; Minocycline belongs to Anti Bacterial.
Why it happens
No established mechanism; reports of ergotism are mainly linked to other antibiotics.
What to do
No empiric dose change is needed. Watch for signs of ergotism such as peripheral coldness, paresthesia or ischemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dihydroergotamine and Minocycline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Minocycline?
MediHelp rates the interaction as minor. Dihydroergotamine and Minocycline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ergotism has been reported with ergot alkaloids and macrolides, which inhibit CYP3A4, but tetracyclines are not CYP3A4 inhibitors. Any interaction with minocycline is poorly supported and most likely theoretical.
How serious is the interaction between Dihydroergotamine and Minocycline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Watch for signs of ergotism such as peripheral coldness, paresthesia or ischemia.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
