Drug interactions
Dihydroergotamine + Sofosbuvir-velpatasvir
Severity: Moderate
Dihydroergotamine and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine is a sensitive CYP3A4 substrate with serious vasospastic toxicity when concentrations rise. Velpatasvir shows only weak CYP3A4 inhibition, so a large effect is unlikely, but the narrow safety margin of ergots warrants attention.
What this interaction means in plain words
Dihydroergotamine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Sofosbuvir-velpatasvir belongs to Anti Virals.
Why it happens
Velpatasvir may weakly inhibit CYP3A4, reducing dihydroergotamine clearance.
What to do
Monitor for ergotism, such as limb coldness, paresthesia or severe headache, and stop dihydroergotamine if it occurs. Consider an alternative migraine therapy if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Dihydroergotamine and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine is a sensitive CYP3A4 substrate with serious vasospastic toxicity when concentrations rise. Velpatasvir shows only weak CYP3A4 inhibition, so a large effect is unlikely, but the narrow safety margin of ergots warrants attention.
How serious is the interaction between Dihydroergotamine and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ergotism, such as limb coldness, paresthesia or severe headache, and stop dihydroergotamine if it occurs. Consider an alternative migraine therapy if possible.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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