Drug interactions
Dihydroergotamine + Timolol
Severity: Moderate
Dihydroergotamine and Timolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine is a vasoconstrictor, and beta-blockade may leave alpha-mediated vasoconstriction unopposed, potentially worsening peripheral ischemia. Cold extremities and, rarely, more serious ischemia can occur.
What this interaction means in plain words
Dihydroergotamine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Timolol belongs to Cardiovascular.
Why it happens
Beta-2 blockade removes vasodilation opposing the ergot-induced vasoconstriction.
What to do
Monitor for cold or painful extremities and numbness. Stop dihydroergotamine if signs of peripheral ischemia occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Timolol
- Acebutolol + Timolol Major
- Aldesleukin + Timolol Major
- Amifostine + Timolol Major
- Amiodarone + Timolol Major
- Arformoterol + Timolol Major
- Atenolol-chlorthalidone + Timolol Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Timolol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Timolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine is a vasoconstrictor, and beta-blockade may leave alpha-mediated vasoconstriction unopposed, potentially worsening peripheral ischemia. Cold extremities and, rarely, more serious ischemia can occur.
How serious is the interaction between Dihydroergotamine and Timolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold or painful extremities and numbness. Stop dihydroergotamine if signs of peripheral ischemia occur.
What other medicines interact with Timolol?
MediHelp also lists interactions of Timolol with, for example, Acebutolol, Aldesleukin, Amifostine. The full list is on the Timolol page.
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