Drug interactions
Dihydroergotamine intranasal + Enzalutamide
Severity: Moderate
Dihydroergotamine intranasal and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower systemic dihydroergotamine levels from the nasal spray and reduce migraine relief. Clinical data are limited.
What this interaction means in plain words
Dihydroergotamine intranasal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 induction by enzalutamide increases dihydroergotamine metabolism.
What to do
Monitor for reduced headache response and consider an alternative acute migraine therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Enzalutamide?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower systemic dihydroergotamine levels from the nasal spray and reduce migraine relief. Clinical data are limited.
How serious is the interaction between Dihydroergotamine intranasal and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced headache response and consider an alternative acute migraine therapy if needed.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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