Drug interactions
Diltiazem + Enzalutamide
Severity: Moderate
Diltiazem and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and can markedly reduce diltiazem exposure. This may cause loss of blood pressure, angina or heart rate control.
What this interaction means in plain words
Diltiazem and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
Induction of CYP3A4 by enzalutamide increases diltiazem metabolism.
What to do
Monitor heart rate and blood pressure and increase the diltiazem dose if needed. Consider a non-CYP3A4 dependent alternative if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Diltiazem with Enzalutamide?
MediHelp rates the interaction as moderate. Diltiazem and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is a strong CYP3A4 inducer and can markedly reduce diltiazem exposure. This may cause loss of blood pressure, angina or heart rate control.
How serious is the interaction between Diltiazem and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and increase the diltiazem dose if needed. Consider a non-CYP3A4 dependent alternative if control is inadequate.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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