Drug interactions
Diltiazem + Maraviroc
Severity: Moderate
Diltiazem and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc is a CYP3A4 substrate, and diltiazem may raise its concentrations, increasing postural hypotension and other adverse effects. Dose adjustment depends on co-administered drugs.
What this interaction means in plain words
Diltiazem and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Diltiazem inhibits CYP3A4-mediated metabolism of maraviroc.
What to do
Monitor for postural hypotension, and consider maraviroc dose reduction per labeling when used with CYP3A inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Diltiazem with Maraviroc?
MediHelp rates the interaction as moderate. Diltiazem and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc is a CYP3A4 substrate, and diltiazem may raise its concentrations, increasing postural hypotension and other adverse effects. Dose adjustment depends on co-administered drugs.
How serious is the interaction between Diltiazem and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for postural hypotension, and consider maraviroc dose reduction per labeling when used with CYP3A inhibitors.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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