Drug interactions
Enzalutamide + Maraviroc
Severity: Major
Enzalutamide and Maraviroc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide can substantially lower maraviroc levels, risking virologic failure. Maraviroc dosing is adjusted when strong CYP3A inducers are used without a CYP3A inhibitor.
What this interaction means in plain words
Enzalutamide and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Maraviroc belongs to Anti Virals.
Why it happens
Enzalutamide induces CYP3A4, increasing maraviroc metabolism.
What to do
Avoid if possible; if needed, increase maraviroc to 600 mg twice daily when not given with a strong CYP3A inhibitor. Monitor HIV viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Maraviroc
Frequently asked questions
Can I take Enzalutamide with Maraviroc?
MediHelp rates the interaction as major. Enzalutamide and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide can substantially lower maraviroc levels, risking virologic failure. Maraviroc dosing is adjusted when strong CYP3A inducers are used without a CYP3A inhibitor.
How serious is the interaction between Enzalutamide and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if needed, increase maraviroc to 600 mg twice daily when not given with a strong CYP3A inhibitor. Monitor HIV viral load.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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