Drug interactions
Clarithromycin + Maraviroc
Severity: Major
Clarithromycin and Maraviroc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin markedly increases maraviroc exposure, raising the risk of postural hypotension and other adverse effects. The interaction is well characterized for strong CYP3A4 inhibitors.
What this interaction means in plain words
Clarithromycin and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clarithromycin belongs to Anti Bacterial; Maraviroc belongs to Anti Virals.
Why it happens
Clarithromycin inhibits CYP3A4 and P-glycoprotein, reducing maraviroc clearance.
What to do
Reduce maraviroc to 150 mg twice daily during clarithromycin therapy unless a CYP3A inducer is also given. Monitor blood pressure and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
- Eslicarbazepine + Maraviroc Major
Frequently asked questions
Can I take Clarithromycin with Maraviroc?
MediHelp rates the interaction as major. Clarithromycin and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin markedly increases maraviroc exposure, raising the risk of postural hypotension and other adverse effects. The interaction is well characterized for strong CYP3A4 inhibitors.
How serious is the interaction between Clarithromycin and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce maraviroc to 150 mg twice daily during clarithromycin therapy unless a CYP3A inducer is also given. Monitor blood pressure and for adverse effects.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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