Drug interactions
Amobarbital + Maraviroc
Severity: Major
Amobarbital and Maraviroc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce maraviroc exposure by inducing CYP3A4, potentially compromising HIV control.
What this interaction means in plain words
Amobarbital and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amobarbital belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
CYP3A4 induction increases maraviroc clearance.
What to do
Maraviroc dose increase is recommended with strong inducers when no potent CYP3A inhibitor is present; otherwise avoid and monitor viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Maraviroc
Frequently asked questions
Can I take Amobarbital with Maraviroc?
MediHelp rates the interaction as major. Amobarbital and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Amobarbital may reduce maraviroc exposure by inducing CYP3A4, potentially compromising HIV control.
How serious is the interaction between Amobarbital and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maraviroc dose increase is recommended with strong inducers when no potent CYP3A inhibitor is present; otherwise avoid and monitor viral load.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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