Drug interactions
Efavirenz + Maraviroc
Severity: Major
Efavirenz and Maraviroc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Efavirenz substantially lowers maraviroc concentrations, which may reduce antiviral efficacy.
What this interaction means in plain words
Efavirenz and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Efavirenz belongs to Anti Virals; Maraviroc belongs to Anti Virals.
Why it happens
Efavirenz induces CYP3A4, increasing the metabolism of maraviroc.
What to do
Increase maraviroc to 600 mg twice daily when used with efavirenz without a strong CYP3A4 inhibitor, per labeling. Monitor viral response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Maraviroc
Frequently asked questions
Can I take Efavirenz with Maraviroc?
MediHelp rates the interaction as major. Efavirenz and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Efavirenz substantially lowers maraviroc concentrations, which may reduce antiviral efficacy.
How serious is the interaction between Efavirenz and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase maraviroc to 600 mg twice daily when used with efavirenz without a strong CYP3A4 inhibitor, per labeling. Monitor viral response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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