Drug interactions
Carbamazepine + Maraviroc
Severity: Major
Carbamazepine and Maraviroc: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine can reduce maraviroc concentrations and threaten antiviral efficacy.
What this interaction means in plain words
Carbamazepine and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Carbamazepine induces CYP3A4, increasing maraviroc metabolism.
What to do
Without a strong CYP3A inhibitor in the regimen, labeling recommends an increased maraviroc dose of 600 mg twice daily; otherwise choose an alternative antiseizure drug. Monitor viral load.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
- Eslicarbazepine + Maraviroc Major
Frequently asked questions
Can I take Carbamazepine with Maraviroc?
MediHelp rates the interaction as major. Carbamazepine and Maraviroc can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine can reduce maraviroc concentrations and threaten antiviral efficacy.
How serious is the interaction between Carbamazepine and Maraviroc?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Without a strong CYP3A inhibitor in the regimen, labeling recommends an increased maraviroc dose of 600 mg twice daily; otherwise choose an alternative antiseizure drug. Monitor viral load.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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