Drug interactions
Diltiazem + Tepotinib
Severity: Minor
Diltiazem and Tepotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and may modestly increase exposure to P-gp substrates such as diltiazem. The clinical significance is likely limited, but additive bradycardia or hypotension is possible.
What this interaction means in plain words
Diltiazem and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diltiazem belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein by tepotinib may increase diltiazem absorption.
What to do
No routine adjustment is needed. Monitor heart rate and blood pressure after starting tepotinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Diltiazem with Tepotinib?
MediHelp rates the interaction as minor. Diltiazem and Tepotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tepotinib inhibits P-gp and may modestly increase exposure to P-gp substrates such as diltiazem. The clinical significance is likely limited, but additive bradycardia or hypotension is possible.
How serious is the interaction between Diltiazem and Tepotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor heart rate and blood pressure after starting tepotinib.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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