Drug interactions
Diltiazem + Vilazodone
Severity: Moderate
Diltiazem and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may raise vilazodone concentrations, increasing serotonergic and other adverse effects such as nausea, diarrhea and serotonin toxicity.
What this interaction means in plain words
Diltiazem and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Vilazodone belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition reduces vilazodone metabolism.
What to do
Monitor for adverse effects and serotonin syndrome symptoms. Reduce vilazodone to 20 mg daily if intolerable effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Diltiazem with Vilazodone?
MediHelp rates the interaction as moderate. Diltiazem and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may raise vilazodone concentrations, increasing serotonergic and other adverse effects such as nausea, diarrhea and serotonin toxicity.
How serious is the interaction between Diltiazem and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects and serotonin syndrome symptoms. Reduce vilazodone to 20 mg daily if intolerable effects occur.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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